FACTORS AFFECTING TUMOR NECROSIS FACTOR RECEPTOR RELEASING ENZYME ACTIVITY

摘要

BIOLOGICAL EFFECTS OF THE SYTCKINE TNF ARE MEDIATED BY BINDING TO TNF RECEPTORS ON THE CELLSURFACE. THIS DISCLOSURE PROVIDES NEW COMPOUNDS THAT PROMOTE ENZYMATIC CLEAVAGE AND RELEASE OF TNF RECEPTORS FROM CELLS, THUS EFFECTING SIGNAL TRANSDUCTION. PROTEINS EFFECTING TNF RECEPTOR RELEASE AND POLYNUCLECTIDE SEQUENCES ENCODING THEM ARE PROVIDED. IN A PHARMACAUTICAL COMPOSITION, THESE PRODUCTS CAN BE ADMINISTERED TO NORMALIZE TNF TRANSDUCTION, THEREBY ALLEVIATING THE SYMPTOMS OF A DISEASE. METHODS ARE ALSO DESCRIBED FOR OBTAINING OTHER COMPOSITIONS THAT PROMOTE OR INHIBIT TNF RECEPTOR RELEASE.