Mutants marburg i of protease activating factor VII (FSAP) as a risk factor for arterial thrombosis.

摘要

Procedures for recognizing an increased risk for the origin and progression of arterial thromboses and atherosclerotic diseases and diseases which are joined such as, for example, angina, heart attack and stroke, characterized in body fluid samples of a donor, especially in blood plasma, or f) the heterozygous presence or homozygous for a mutant FSAP proenzyme with an exchange base G / a at nucleotide position 1601 by analysis of the genomic DNA of the donor or detected one mRNA derived from this and / or g) the presence of an FSAP mutant protein level, which has lost the ability to activate the plasminogen activators single chain, or in which at least has impaired this ability is detected and / or h) the presence of specific antibodies is detected against an FSAP mutant which has lost the ability to activate activators plasm inógenos single chain, or in which at least it has impaired the ability and / or i) a reduced potential of FSAP to activate the plasminogen activators single chain and / or j) is detected a reduced concentration is detected FSAP antigen.