PIPERIDINE AND PIPERAZINE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY, EATING DISORDERS AND SEXUAL DYSFUNCTION BY POTENTIATION OF MC4 RECEPTOR ACTIVITY

摘要

The present invention provides methods of treating obesity, eating disorders, and sexual dysfunction. The methods comprise administering to a mammalian host suffering from obesity, an eating disorder, or sexual dysfunction an effective dose of a compound of the invention. Also provided are methods of potentiating the effect of an MC4 receptor agonist in a mammalian host. In some cases the methods comprise administering to the host a compound that lowers the EC50 of the agonist. In other cases the methods comprise administering to the host a compound that increases the maximum effect of the agonist.