FUNCTION OF ESTROGEN RELATED RECEPTOR GAMMA (ERRγ) IN INCREASING MITOCHONDRIAL BIOGENESIS

摘要

The present invention relates to the novel method for identifying an ERRγ agonist that enhances the mitochondriogenesis. The ERRγ agonist can be a chemical compound or a polypeptide. The present invention further relates to the use of the ERRγ agonist in the treatment of diseases selected from diabetes, type 2 diabetes, insulin resistance, metabolic disease/metabolic syndrome, dyslipidemia, obesity/overweight, neurodegenerative diseases. Furthermore, the compound is useful for improving exercise endurance capacity in a subject.