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FORMULATION FOR INHALATION COMPRISING A GLUCOCORTICOID AND A BETA 2-ADRENORECEPTOR AGONIST

机译:包含糖皮质激素和β2-肾上腺素能受体激动剂的吸入剂配方

摘要

According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula I, wherein R1 represents C1-6 alkyl or C1-6 haloalkyl R2 represents -C=O-aryl or -C=O-heteroaryl R3 represents hydrogen, methyl which may be in either the alpha or beta configuration or methylene R4 and R5 are the same or different and each represents hydrogen or halogen and a represents a single or a double bond and salts and solvates thereof together with a long-acting beta2-adrenoreceptor agonist which formulation has a therapeutically useful effect in the treatment of inflammatory disorders of the respiratory tract over a period of 24 hours or more.
机译:根据本发明的一个方面,提供了一种用于吸入给药的药物制剂,其包含式I的化合物,其中R 1代表C 1-6烷基或C 1-6卤代烷基R 2代表-C = O-芳基或-C = O -杂芳基R3代表氢,甲基,其可以为α或β构型或亚甲基R4和R5相同或不同,各自代表氢或卤素,并且a代表单键或双键,其盐和溶剂化物与a长效β2-肾上腺素受体激动剂,该制剂在24小时或更长时间的治疗呼吸道炎性疾病中具有治疗上有用的作用。

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