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INTRAGASTRIC FLOATING-TYPE LEVODOPA SUSTAINED-RELEASE PREPARATION

机译:胃内漂浮型左旋多巴持续释放制剂

摘要

The object is to maintain the sustained blood level of levodopa and to provide a levodopa preparation which enables the sustained release of levodopa in the stomach and has a satisfactory intragastric floating time, has a size that is easy to be administered, and can be produced industrially. Specifically disclosed is a levodopa intragastric floating preparation which comprises: a drug release layer comprising levodopa; and an intragastric floating layer showing a satisfactory floating property in the stomach which relies on it high mechanical strength and showing a good disintegrating property in the intestinal tract.
机译:目的是维持左旋多巴的持续血液水平,并提供一种左旋多巴制剂,其能够使左旋多巴在胃中持续释放并具有令人满意的胃内漂浮时间,具有易于施用的尺寸,并且可以工业化生产。 。具体公开了一种左旋多巴胃内漂浮制剂,其包括:包含左旋多巴的药物释放层;和包含左旋多巴的药物释放层。胃内漂浮层在胃中显示出令人满意的漂浮性,这取决于它的高机械强度并在肠道中表现出良好的崩解性。

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