ANTHELMINTIC MACROLACTAMS FROM NONMURAEA TURKMENIACA MA 7364

摘要

Novel macrolactams, 6-desmethyl-N-methylfluvirucin A1 and N-methylfluvirucin A1, isolated from the acetone extract of Nonomuraea turkmeniaca MA7364 using bioassay-guided fractionation, useful as anthelmintics; characterization of structure of 6-desmethyl-N-methylfluvirucin A1 and N-methylfluvirucin A1 via NMR and MS; and characterization of biological activity of 6-desmethyl-N-methylfluvirucin A1 and N-methylfluvirucin A1.