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INHIBITION OF ATP-MEDIATED, P2X7 DEPENDENT PATHWAYS BY PYRIDOXAL-5-PHOSPHASTE AND VITAMIN B6 RELATED COMPOUNDS
INHIBITION OF ATP-MEDIATED, P2X7 DEPENDENT PATHWAYS BY PYRIDOXAL-5-PHOSPHASTE AND VITAMIN B6 RELATED COMPOUNDS
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机译:吡咯醛-5-磷和维生素B6相关化合物对ATP介导的P2X7依赖性途径的抑制作用
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摘要
P5P can be used as effective treatments for the modulation of P2X7, IL-1beta, and inflammation response, and for diseases in which prevention of P2X7-dependent pathways or prevention of release of IL-1beta is desirable, such as epithelial cancer, leukemia, brain tumors, spinal cord injury, tuberculosis, Alzheimer's Disease, neurodegenerative diseases, autosomal recessive polycystic kidney disease, diabetes, including type I diabetes, prostate cancer, and osteoporosis, bone formation and resorption.
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