PREPARATION OF DRUG DELIVERY SYSTEMS USING PH-SENSITIVE BLOCK COPOLYMER AND THEIR APPLICATION

摘要

Disclosed is a drug delivery system, which encapsulates a hydrophobic drug and consists of a pH-sensitive block copolymer having both hydrophilic segments and hydrophobic segments. Due to its high pH-sensitivity, the drug delivery system selectively delivers a great amount of a drug to a diseased region within a short period of time by being easily degraded at a locally low ph in a variety of cancerous or inflammatory disease regions, thereby enhancing therapeutic effectiveness of the drug as well as remarkably reducing toxicity of the drug itself, thus to be useful for treatment against a variety of cancers or inflammatory diseases.