MECHANISMS OF OSTEOINDUCTION BY LIM MINERALIZATION PROTEIN-1 (LMP-1)

摘要

The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics.