A PURIFIED EXTRACT ISOLATED FROM SALVIA MILTIORRHIZA, A METHOD FOR PREPARING THEM AND THE COMPOSITION COMPRISING THE SAME HAVING HEPATO-PROTECTING ACTIVITY AND PROTECTING OR TREATING ACTIVITY FROM LIVER FIBROSIS AND LIVER CIRRHOSIS

摘要

A method for preparing a purified extract of Salvia miltiorrhiza is provided to obtain the extract which contains cryptotanshinone, tanshinone I and tanshinone IIA at high concentration and show excellent liver protecting effect, antifibrotic effect, and liver cell apoptosis inhibitory effect, thereby being usefully used as a pharmaceutical composition and a health supplement food for treating and preventing hepatic fibrosis or liver cirrhosis. A method for preparing a purified extract of Salvia miltiorrhiza comprises the steps of: (a) preparing a crude extract of dried Salvia miltiorrhiza by extraction with a lower alcohol solvent, filtration, concentration under reduced pressure and drying; (b) suspending the crude extract in water and then filtering the suspension to obtain a water-insoluble residue; (c) after adding lower alcohol to the residue, agitating, dissolving and filtering it to obtain filtrate; and (d) removing solvent remaining from the filtrate. A pharmaceutical composition comprises the purified extract of Salvia miltiorrhiza as an effective ingredient, and a pharmaceutically acceptable carrier or an excipient.