DETECTION KIT FOR EPILEPSY BY MEASURING THE EXPRESSION OF EPILEPSY MARKER GENES

摘要

20 kinds of lowly expressed genes in an epilepsy tissue as an epilepsy marker are provided to be quantified in a patient tissue rapidly and sensitively, thereby being very usefully used for diagnosing the epilepsy. A kit for detecting epilepsy by measuring the expression of a lowly-expressed gene in an epilepsy tissue comprises at least one selected from the group consisting of the lowly-expressed gene in an epilepsy tissue selected from the group consisting of GAPDH, TSC22, TTR, DEPP, SPP1, ACTG2, ID2, HNLF, CPE, MBP, LDHA, HSPA9B, A2BP1, PPP2CA, ATP6VE1, MAP2, MGC8685, HLA-C, ARF1 and VSNL1, a complimentary probe thereof, a sense primer and an antisense primer of the gene having a sequence of SEQ ID : NOs. 5 to 46. A method for screening an epilepsy inhibitor comprises the steps of: (a) binding at least one protein encoded by the gene to a test compound; and (b) fixing the protein to an affinity chromatography column and contacting it with a sample to be tested so as to identify whether the test compound promotes or inhibits the action of the protein through purification, a two-hybrid method, a western blotting method or a high-throughput screening method.