PREPARATION METHOD OF BIODEGRADABLE POROUS POLYMER SCAFFOLDS CONTAINING HYDROXYAPATITE FOR TISSUE ENGINEERING

摘要

A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.