Agonist compounds that can specifically recognize and cross-linking of cell surface molecules or intracellular MOLECULE

摘要

1.a compound containing two or more h chain v regions and two or more l chain v regions u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0433u043e antibodies and u043eu0431u043du0430u0440u0443u0436u0438u0432u0430u044eu0449u0435u0435 equivalent or better agonist u0438u0447u0435u0441u043au043eu0435 effects (ED50) in comparison with the natural u043bu0438u0433u0430u043du0434u043eu043c, which u0441u0432u00a0u0437u044bu0432u0430u0435u0442u0441u00a0 molecule (or molecules) of cell surface molecule (u043cu043eu043bu0435u043au0443 u0432u043du0443u0442u0440u0438u043au043bu0435u0442u043eu0447u043du043eu0439 lamy)where the connection u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a whole antibody or a f (ab ') 2 capable of specifically recognizing and transverse stitching molecule (molecules) of cellular u043fu043eu0432u0435u0440u0445u043du043eu0441 ti or u0432u043du0443u0442u0440u0438u043au043bu0435u0442u043eu0447u043du0443u044e molecule (u0432u043du0443u0442u0440u0438u043au043bu0435u0442u043eu0447u043du044bu0435 molecules).;2. connection for 1, which detects at least 2 times more u0430u0433u043eu043du0438u0441u0442u0438u0447u0435u0441u043au043eu0435 effects (ED50) in comparison with the natural u043bu0438u0433u0430u043du0434u043eu043c, which u0441u0432u00a0u0437u044bu0432u0430u0435u0442u0441u00a0 with u043cu043eu043bu0435u043au0443 loy (molecules) to the cell surface or u0432u043du0443u0442u0440u0438u043au043bu0435u0442u043eu0447u043du043eu0439 molecule (u0432u043du0443u0442u0440u0438u043au043bu0435u0442u043eu0447u043du044bu043cu0438 molecules).;3. connection for 2, which detects at least 10 times more u0430u0433u043eu043du0438u0441u0442u0438u0447u0435u0441u043au043eu0435 effects (ED50) in comparison with the natural u043bu0438u0433u0430u043du0434u043eu043c, which u0441u0432u00a0u0437u044bu0432u0430u0435u0442u0441u00a0 with molecules oh (molecules) to the cell surface or u0432u043du0443u0442u0440u0438u043au043bu0435u0442u043eu0447u043du043eu0439 molecule (u0432u043du0443u0442u0440u0438u043au043bu0435u0442u043eu0447u043du044bu043cu0438 molecules).;4. modified antibody or connection to any of the u043fu043f.1 - 3, which essentially has a laser u0430u0434u0433u0435u0437u0438u043eu043du043du043eu0433u043e u0434u0435u0439u0441u0442u0432u0438u00a0.;5. the connection of any of the u043fu043f.1 - 3, which is u043cu0435u0436u043au043bu0435u0442u043eu0447u043du043eu0435 u0430u0434u0433u0435u0437u0438u043eu043du043du043eu0435 effects (ED50), u0441u043eu0441u0442u0430u0432u043bu00a0u044eu0449u0435u0435 not more than 1 / 10 compared with the original u0430u043du0442u0438u0442u0435u043bu043eu043c.