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OPTIMIZED ADMINISTRATION OF DOSES OF ANTI-CD4-ANTIBODIES FOR TOLERANCE INDUCTION IN PRIMATES
OPTIMIZED ADMINISTRATION OF DOSES OF ANTI-CD4-ANTIBODIES FOR TOLERANCE INDUCTION IN PRIMATES
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机译:原始耐受性的抗CD4抗体剂量的优化管理
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摘要
The present invention is based, at least in part, on the finding that tolerance can be induced by inhibition of CD4+ cells (and optionally CD8+ cells). Accordingly, the optimized dosing methods of the invention are useful in treating a primate, e.g., a human, by inhibiting CD4+ T cells to induce tolerance to at least one antigen, e.g., self or foreign, such as for inducting tolerance in a primate against a soluble or a cell bound antigen (e.g., an allogeneic or xenogeneic transplanted antigen).
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