4-OXO-1-(3-SUBSTITUTED PHENYL)-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF, METHOD FOR TREATMENT AND PROPHYLAXIS AND METHOD FOR IMPROVING COGNITIVE ABILITY IN HEALTH SUBJECT

摘要

FIELD: organic chemistry, medicine, pharmacy.;SUBSTANCE: invention describes novel 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamides of the general formula (I): or their pharmaceutically acceptable salts wherein Ar means phenyl or thienyl; Y means -COOH, (C₁-C₆)-alkyl, (C₁-C₄-alkyl)_n-COOH, (C₃-C₄)-cycloalkyl-COOH wherein (C₁-C₆)-alkyl and (C₃-C₄)-cycloalkyl are optionally substituted with halogen atom, hydroxy-group, -CN, and (C₁-C₄)-alkyl-substitutes are bound optionally to form (C₃-C₄)-cycloalkyl and wherein n = 0, 1, 2, 3 or 4; R means hydrogen atom (H) or (C₁-C₆)-alkyl; R¹ means H, (C₁-C₆)-alkyl optionally substituted with halogen atom; (C₃-C₆)-cycloalkyl optionally substituted with halogen atom, (C₁-C₆)-alkyl, -OH, -CN or phenyl; (C₁-C₆-alkyl)-SO_p-(C₁-C₆)-alkyl wherein p = 0, 1 or 2; or 1,3,4-thiadiazolyl substituted with halogen-(C₁-C₆)-alkyl; or R¹ means methyl substituted with cyclopropyl; R² means H, halogen atom or (C₁-C₆)-alkyl; R³ means H or halogen atom, and pharmaceutical compositions based on thereof. Compounds possess inhibitory activity and can be used in treatment of asthma and inflammatory diseases.;EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions, improved method of treatment.;22 cl, 4 tbl, 30 ex