METHOD OF ADJUVANT IMMUNOTHERAPY OF PRIMARY AND METASTATIC MALIGNANT UNRESECTABLE LIVER TUMOURS

摘要

FIELD: medicine; immunotherapy.;SUBSTANCE: indications for adjuvant immunotherapy of primary and metastatic malignant unresectable liver tumours are determined. For this purpose within surgical process incision biopsy of tumour and healthy liver tissue is performed. Then immediately after operation lymphocytes of tumour tissue, healthy tissue and peripheral blood by markers CD4+, CD8+, CD16+, CD56+ are immunophenotyped. In case lymphocyte marker levels CD4+, CD8+ and NK-cells levels CD16+ and CD56+ are lowered more than 10% for tumour tissue and peripheral blood in comparison with healthy tissue and peripheral blood, postoperative intraportal prolonged introduction of rhoncoleukin is indicated.;EFFECT: provides accurate direct evaluation of local immunity condition; enables to improve treatment results.;12 dwg, 4 tbl, 1 ex