Use of lactic acid compounds as tumor necrosis factor-alpha blocker, e.g. for suppressing immune system, for prophylaxis and/or treatment of autoimmune diseases and/or inflammatory diseases, preferably rheumatoid arthritis, spondylitis

摘要

Use of lactic acid compounds (I) of formula (R2-CH2-C(R3)(R4)-C(=O)-O-R1) for the suppression of the immune system, is claimed. Use of compounds of formula (I) for the suppression of the immune system, is claimed. R1alkyl-, alkenyl-, cycloalkyl-, alkoxyalkyl-, alkoxycarbonylalkyl- or aryl; R2H, alkyl-, alkenyl-, cycloalkyl-, alkoxyalkyl-, alkoxycarbonylalkyl or aryl; either R3-OH; and R4H; or R3-H and R4-OH. ACTIVITY : Immunosuppressive; Antiinflammatory; Antiarthritic; Antirheumatic; Osteopathic; Antibacterial; Antimalarial; Cerebroprotective; Respiratory-Gen; Vasotropic; Gastrointestinal-Gen; Antiulcer; Antipyretic; Anabolic. MECHANISM OF ACTION : Tumor necrosis factor-alpha blocker; Major histocompatibility complex molecule blocker; Interferon-gamma blocker. Tests details are described but no results given.