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Peptide useful for specifically killing cells comprises a sequence capable of coupling to a specific-binding molecule, an oligomerization sequence and a sequence for binding a cytotoxic component
Peptide useful for specifically killing cells comprises a sequence capable of coupling to a specific-binding molecule, an oligomerization sequence and a sequence for binding a cytotoxic component
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机译:用于特异性杀死细胞的肽包括能够与特异性结合分子偶联的序列,寡聚序列和结合细胞毒性成分的序列。
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摘要
New peptide (I) comprises a sequence A capable of coupling to a molecule that specifically binds to biological structures, an oligomerization sequence B and a sequence C for binding a component that is cytotoxic on contact with a target. An independent claim is also included for a macromolecular structure comprising (I) covalently bound through an amino acid X (glutamine, asparagine or cysteine) to a component (II) that specifically binds to biological structures. ACTIVITY : Cytostatic; Antiparasitic. No biological data given. MECHANISM OF ACTION : None given.
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机译: 结合人CD20的人单克隆抗体,该抗体能够在存在补体的情况下诱导表达CD2的细胞的补体依赖性细胞毒性,并且包含根据EP1558648B1的权利要求1的轻链和重链CDR区, i),(ii)(a)和(iii)(SEQ ID Nos.16、17、18、13、14和15),特别是包含轻链和重链可变区序列的抗体根据EP1558648B1的权利要求4(SEQ ID Nos.4和2),特别是ofatumumab