For the human cd40 - receptor coding cdna - region homologous oligo ribo nucleotide sequence as well as related duplex - oligoribonucleotides, vectors, pharmaceutical compositions and uses

摘要

The invention relates to oligoribonucleotide sequences 5'-gcgaauuccuuagacaccug-3' and 5'-caggugucuaggaauucgc-3' which are homologous to the region comprised between nucleotides 241 and 259 in the cDNA which codes for the human CD40 receptor, as found in the GeneBank under accession number X60592, as well as sequences and duplex oligonucleotides derived therefrom. The invention also refers to pharmaceutical compositions comprising them, to genic transfer vectors capable of inducing their expression and their use for preparing medicaments, for example for inhibiting the expression of the human CD40 receptor, for blocking or reducting the interaction between human CD40 and CD40L, etc..