SPECIFIC MARKER FOR OXIDATIVE DEGRADATION OF TISSUES CONTAINING TYPE III COLLAGEN, MEANS AND METHODS, DIAGNOSTIC KITS FOR MONITORING OR PROGNOSIS OF THE PATHOLOGIES TARGETED BY THIS MARKER.

摘要

The present invention relates to a novel peptide marker specific for oxidative degradation of tissues containing type III collagen and preferably nitrosylation of type III collagen. The main objective is to provide a specific and early or pre-symptomatic marker of diseases that are accompanied by oxidative degradation of tissues containing type III collagen, particularly inflammatory conditions such as osteoarticular diseases. The marker according to the invention is characterized in that it comprises at least one peptide sequence of 5 to 25 amino acids, preferably 5 to 20 AA, and even more preferably 4 to 15 AA, the sub-component of which QYDSYD sequence in which at least one of the Y is nitrosylated and where Q corresponds not only to glutamine but also to pyroglutamic acid.The invention also relates to means and methods and diagnostic kits for monitoring or prognosis of pathologies targeted by this marker, especially for inflammatory conditions such as osteoarticular diseases.