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Aqueous emulsion for intravenous injection, contains insoluble active agent, e.g. cyclosporin A, and fatty acid metal salt and polyethylene glycol hydroxystearate as solubilizers
Aqueous emulsion for intravenous injection, contains insoluble active agent, e.g. cyclosporin A, and fatty acid metal salt and polyethylene glycol hydroxystearate as solubilizers
An aqueous pharmaceutical emulsion (I) for intravenous injection contains (A) a water-insoluble active agent (other than propofol) and (B) a stabilizing system comprising 5-23C fatty acid monovalent metal salt(s) (II) and polyethylene glycol hydroxystearate(s) (III). An independent claim is included for the preparation of (I), by adding (A) (predissolved in a solvent) to a mixture of water, the (II)/(III) solubilizing system (B) and an adjuvant system comprising a solvent, a polyoxyethylene compound, a pH controller, an osmolarity controller and/or a structuring agent.
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