NEW RECOMBINANT HERPESVIRUS OF TURKEY, AND VACCINE FOR DOMESTIC FOWL UTILIZING THE SAME

摘要

PPROBLEM TO BE SOLVED: To provide a recombinant HVT (herpesvirus of turkey) having vaccine effects on avian IB (infectious bronchitis). PSOLUTION: The recombinant HVT is obtained by inserting a gene encoding a spike protein of the avian IBV (infectious bronchitis virus), a gene encoding a membrane protein, and a gene encoding an envelope protein together with a promoter into a genome. A promoter selected from among the group consisting of an initial promoter of cytomegalovirus, a promoter of an avian β-actin gene, and a promoter of UL50 gene of Marek's disease virus is preferable. The gene encoding each of the proteins is preferably inserted between open leading frames of UL45 and UL46 of the HVT. PCOPYRIGHT: (C)2009,JPO&INPIT