NEW AMPLICON IN 20q13 REGION OF HUMAN CHROMOSOME 20 AND USES THEREOF

摘要

PPROBLEM TO BE SOLVED: To provide a clear characterization of nucleic acid sequence in 20q13 relevant to neoplasm phenotype. PSOLUTION: The invention pertains to the field of cancer genetics and cytogenetics. In particular, the invention pertains to the identification of a new amplicon on human chromosome 20 which is associated with cancer. More particularly the invention pertains to the identification of a new "amplicon" or genomic nucleic acid in a region of amplification at about 20q13.2 which has been associated with a variety of cancers, (particularly breast cancer). The new amplicon can be used as a probe specific for this region of 20q13.2 as well as for the diagnosis and prognosis of various cancers. Also provided are kits for screening for the presence and copy number of the new amplicon in a sample containing human nucleic acid. PCOPYRIGHT: (C)2009,JPO&INPIT