NOVEL AMPLICON IN 20q13 REGION OF HUMAN CHROMOSOME 20 AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide definitive characterization of nucleic acid sequences in 20q13 associated with tumor phenotypes.SOLUTION: This invention pertains to the field of cancer genetics and cytogenetics. In particular, this invention pertains to the identification of nucleic acid sequences associated with a novel amplicon on human chromosome 20 which is associated with cancer. More particularly this invention pertains to the identification of a novel "amplicon" or genomic nucleic acid in a region amplification at about 20q13.2 associated with various cancers, particularly breast cancers. The new amplicon can be used as a probe specific to the region of 20q13.2 and also for the diagnosis and prognosis of various cancers. The invention also provides a kit for screening for the presence of an amplicon and copy number in a sample of human nucleic acid.