METHOD OF MANUFACTURING GLYOXYLIC ACID ESTER DIMER, AND NOVEL GLYOXYLIC ACID ESTER DIMER

摘要

PROBLEM TO BE SOLVED: To provide a stable glyoxylic acid ester dimer and a method of manufacturing the same.;SOLUTION: The glyoxylic acid ester dimer shown by the formula: H-[O-C(-C(=O)-O-R')-]₂-OH is obtained by steps of: reacting a glyoxylic acid ester shown by the formula: R'-O-C(=O)-CHO, wherein R' is a menthyl group of an optically active substance or racemic modification, with water while warming in an organic solvent; thereafter cooling; and drying the resulting crystallized substance under decompression. This glyoxylic acid ester dimer is a stable compound, becomes a glyoxylic acid ester-monohydrate by adding excessive water in a suitable solution, and returns to glyoxylic acid ester easily by carrying out heating reflux in a solvent having azeotropy.;COPYRIGHT: (C)2010,JPO&INPIT