ENHANCED IMMUNOGEN FOR INACTIVATED VACCINE FOR INFECTION WITH JAPANESE ENCEPHALITIS VIRUS AND METHOD FOR PRODUCING THE SAME

摘要

PPROBLEM TO BE SOLVED: To provide a technique for mass-producing viral particles by using cell strains instead of mice. PSOLUTION: The present invention provides novel inactivated viral particles as an enhanced immunogen having a titer enhanced by about 2 to 10 times as much as that of the conventional vaccines and a method for producing the enhanced immunogen. These inactivated viral particles are useful also in diagnostic agents for infectious diseases caused by a group of Japanese encephalitis viruses. As a result, production cost is not only remarkably reduced, but its production operation procedure, purification process, quality control, production plan, etc., are also saved. PCOPYRIGHT: (C)2010,JPO&INPIT