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Cancer Therapy and Stem Cell Modulation Methods Cross Reference for Methods Related Applications for Cancer Treatment and Stem Cell Regulation
Cancer Therapy and Stem Cell Modulation Methods Cross Reference for Methods Related Applications for Cancer Treatment and Stem Cell Regulation
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机译:癌症治疗和干细胞调节方法的交叉引用与癌症治疗和干细胞调节相关方法的应用
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摘要
The present invention relates to a method of modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of the general formula (I) In the general formula A is C or N. R 1 , R 4 and R 5 are, independently selected, H or aliphatic, cycloaliphatic, aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0 - 3 heteroatoms being N, O, S, or Si. R 4 and R 5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R 2 is H or a halogen, such as F or Cl. R 3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1 - 8 main chain carbon atoms and 0 - 3 heteroatoms being N, O, S, Si, or a halogen such as Cl or F. Also provided is a method for modulating gene expression in a cell that expresses the components of a polycomb repressive complex.
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机译:本发明涉及调节干/祖细胞的多能性和/或自我更新特性的方法。该方法包括向各个细胞施用通式(I)的化合物。通式A中的C为或N。R 1,R 4和R 5独立地选自H或脂族,脂环族,芳族,芳基脂族,或芳基脂环族烃基,其包含0、3个杂原子为N,O,S或Si。 R 4和R 5可以任选地连接以定义脂族烃基桥。 R 2是H或卤素,例如F或Cl。 R 3是H或包含1-8个主链碳原子和0-3个杂原子的N,O,S,Si或卤素如Cl或F的脂族或芳基脂族烃基。还提供了一种调节方法基因在细胞中表达,表达多梳抑制复合物的成分。
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