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ropibakain hydrochloride anhydride and its manufacturing
ropibakain hydrochloride anhydride and its manufacturing
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机译:罗哌卡因盐酸盐酸酐及其制造
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摘要
As for this invention, stability being method in order to manufacture anhydrous ropibakain hydrochloride, as for particular method, it includes the fact that ropibakain hydrochloride is manufactured from ropibakain base, the ropibakain base is offered, possessing the kiraru purity of 95%, or more, particular isolation includes the use of isopropanol and hydrochloride, regards the method of being done under the condition of water free. The ropibakain base under existing of the portable catalyst between phases, can be offered with high kiraru purity L-pipekorin acid 2,6 - by to N-puropiru converting kishirijido hydrochloride. Furthermore as for this invention, the stability which is obtained by the above-mentioned method it regards anhydrous ropibakain hydrochloride.
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