IMPROVED PROCESS FOR THE MANUFACTURE OF METHAQUALONE AND METHAQUAIONE HYDROCHLORIDE FROM ISATOIC ANHYDRIDE

摘要

A process for the production of methaqualone for formula IIIAnd methaqualone hydrochloride which comprises reacting compound of formula IV with a compound of formula Vto obtain a compound of formula IIand reacting said compound of formula II with a compound of formula Iin the presence of a hydrocarbon solvent under azetropic conditions and, if desired, converting said methqalone of formula III into its hydrochloride with 1-3N hydrochloric acid.