Immunocompetent cells having anti-CD38 antibody on the cell surface

摘要

Amplification of cDNA using immunocompetent cells in which DNA encoding a part of the anti-CD38 antibody is introduced and the anti-CD38 antibody is expressed on the cell surface, and mRNA encoding the anti-CD38 antibody isolated from the hybridoma The inserted cDNA is inserted into a retroviral vector, and the vector is transfected into a packaging cell to produce a packaging cell that produces an anti-CD38 antibody-expressing retroviral particle. A method for producing immunocompetent cells in which human immunocompetent cells are infected and the antibody is expressed on the cell surface.