The vector hKir2.1pcDNA3.1 which is displayed with the below-mentioned chemical formula 1 which includes the human Kir2.1 gene which the kalium channel which in the HEK293

摘要

PROBLEM TO BE SOLVED: To provide a new-character cell line transduced with a calcium channel, and to provide a high-efficiency method for retrieving a T-type α1H calcium channel inhibitor based on the cell line.;SOLUTION: The cell line is provided, being such that a vector containing a gene encoding a potassium channel is transduced into a cell expressing the T-type α1H calcium channel. The method for retrieving a T-type α1H calcium channel inhibitor using the cell line is also provided. The cell line is usefully usable for the high-efficiency retrieve of T-type α1H calcium channel inhibitor candidates, therefore the development of curatives for many diseases caused by the expression abnormalities of the T-type α1H calcium channel can be accelerated.;COPYRIGHT: (C)2006,JPO&NCIPI