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Preventive and therapeutic agent for arteriosclerosis and vascular restenosis after PTCA surgery
Preventive and therapeutic agent for arteriosclerosis and vascular restenosis after PTCA surgery
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机译:PTCA手术后的动脉硬化和血管再狭窄的预防和治疗剂
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摘要
The present invention provides a pharmaceutical composition for the prevention or treatment of angiostenosis, comprising a compound inhibiting the function of midkine (MK) in blood vessel tissues as an effective ingredient. The present invention is useful for the prevention or treatment of angiostenosis attributed to arteriosclerosis or restenosis after percutaneous transluminal coronary angioplasty (PTCA). As compounds inhibiting the function of MK, antisense oligonucleotides that bind to a segment of a single-stranded mRNA transcribed from the MK gene to inhibit the synthesis of MK protein in cells, antibodies against the MK protein, and such can be used.
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