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Pharmaceutical composition containing a PPAR regulator

机译:含有PPAR调节剂的药物组合物

摘要

An object of the present invention is to provide a pharmaceutical composition that is excellent as a preventive or therapeutic agent for diseases related to immune action such as autoimmune diseases. In the present invention, 1 or 2 or more selected from the group consisting of PPAR regulators and the following general formula (I) [wherein R1 and R2 are the same or different and each represents a hydrogen atom or the like, and R3 represents a C1-C6 alkyl] R4 represents a hydrogen atom, a C1-C6 alkyl group, or the like, and R5 represents a group selected from the group consisting of a hydrogen atom, a halogen atom, a cyano group, a C1-C6 alkyl group, and the like. 1 to 3 substituted phenyl groups, X represents a vinylene group (CH = CH group), an oxygen atom, etc. Y represents a single bond, an oxygen atom, etc. Z represents a single bond, C1- C8 alkylene group etc. are shown, n shows the integer of 2 or 3. ] The pharmaceutical composition containing 1 or 2 or more selected from the group which consists of the amino alcohol derivative which has these, and its pharmacologically acceptable salt.
机译:本发明的目的是提供一种优异的药物组合物,其作为与免疫作用有关的疾病例如自身免疫疾病的预防或治疗剂是极好的。在本发明中,选自PPAR调节剂和以下通式(I)中的1个或2个以上[式中,R 1和R 2相同或不同,分别表示氢原子等,R 3表示氢。 [C 1 -C 6烷基] R 4表示氢原子,C 1 -C 6烷基等,R 5表示选自氢原子,卤素原子,氰基,C 1 -C 6烷基的基团。组之类的。 1-3个取代的苯基,X表示亚乙烯基(CH = CH基),氧原子等。Y表示单键,氧原子等。Z表示单键,C1-C8亚烷基等。表示n,表示2或3的整数。]含有选自具有这些的氨基醇衍生物及其药理学上可接受的盐的选自1个或2个以上的药物组合物。

著录项

  • 公开/公告号JPWO2006137509A1

    专利类型

  • 公开/公告日2009-01-22

    原文格式PDF

  • 申请/专利权人 第一三共株式会社;

    申请/专利号JP20070522373

  • 申请日2006-06-23

  • 分类号A61K31/40;A61K31/427;A61P37/06;A61P29;A61P19/02;A61P17/06;A61P25;A61P1/04;C07D207/335;C07D417/12;

  • 国家 JP

  • 入库时间 2022-08-21 19:37:03

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