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Genetic Polymorphisms As Predictive Diagnostics For Adverse Drug Reactions (ADR) And Drug Efficacy

机译:遗传多态性作为药物不良反应(ADR)和药物功效的预测诊断

摘要

The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.
机译:本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒,以及包括确定人类受试者在他汀类药物治疗后是否有发生不良药物反应风险或人类受试者是高反应还是低反应或良好反应的抗体的抗体。他汀类药物的代谢不良或代谢不良。本发明提供了进一步的诊断方法和试剂盒,包括确定人类受试者是否处于心血管疾病危险中的抗体。另外,本发明提供了多态性序列和其他基因。

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