N-Pyrrolidin-3YL-Amide Derivatives As Serotonin and Noradrenalin Re-Uptake Inhibitors

摘要

A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R¹ is H, C_1-6alkyl, —C(A)D, C_3-8cycloalkyl, aryl, het, aryl-C_1-4alkyl or het-C_1-4alkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted by at least one substituent independently selected from C_1-8allkyl, C_1-8alkoxy, OH, halo, CF₃, OCHF₂, OCF3, SCF₃, hydroxy-C_1-6alkyl, C_1-4alkoxy-C_1-6alkyl and C_1-4alkyl-S—C_1-4alkyl; A is S or O; D is H, C_1-6alkyl, aryl, het, aryl-C_1-4alkyl or het-C_1-4alkyl; R² represents aryl¹ or het¹, each of which is substituted by at least one substituent independently selected from B, provided that when R² is substituted by halo then it is also substituted with at least one other substituent independently selected from B other than halo; B represents aryl², het², Oaryl², Ohet², Sarl², Shet², SC_1-6alkyl, halogen, CHF₂, OCHF₂, CF₂CF₃, CH₂CF₃, CF2CH₃, aryl²-C_1-4alkyl, C_3-6cycloalkyl, C_3-6cycloalkyl-C_1-4alkyl, C_3-6cycloalkylC_1-4alkoxy, C_3-6cycloalkyl-O—C_1-4 alkyl, C_3-6cycloalkyl-C_1-4alkoxy-C_1-4alkyl, OC_3-6cycloalkyl, SC_3-6cycloalkyl; wherein the aryl² and het² groups are optionally substituted by at least one group selected from C_1-6alkyl, C_3-6cycloalkyl, C_1-6alkoxy, OC_3-6cycloalkyl, halo, CN, OH, CF₃, CHF₂, OCF₃, OCHF₂, hydroxyC₁$alkyl, C_1-4alkoxy-C_1-4alkyl, SC_1-6alkyl and SCF₃; n is 1 or 2, provided that when n is 1, m is 0 or 1 and when n is 2, m is 0, wherein if m is 0, then * represents a chiral centre; R³ is H, C_1-6alkyl, C_3-8cycloalkyl, C_3-8cycloalkylC_1-6alkyl, aryl³, het³, aryl³-C_1-4alkyl or het³-C_1-4alkyl, wherein the C_3-8cycloalkyl, aryl³ or het³ groups are optionally substituted by at least one substituent independently selected from C_1-6alkyl, C_1-6alkoxy, CN, OH, halo, CF₃, OCF₃, SCF₃, hydroxy-C_1-6alkyl, C_1-4alkoxy-C_1-6alkyl and C_1-4alkyl-S—C_1-4alkyl; at each occurrence aryl, aryl¹, aryl² and aryl³ independently represent phenyl, naphthyl, anthracyl or phenanthryl; het¹ represents an aromatic 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to an aryl group; at each occurrence het, het², and het³ independently represents an aromatic or non-aromatic 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6-membered carbocyclic group or a second 4-, 5- or 6membered heterocycle which contains at least one N, O or S heteroatom.;