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IN VIVO SELECTION SYSTEM FOR ENZYME ACTIVITY
IN VIVO SELECTION SYSTEM FOR ENZYME ACTIVITY
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机译:酶活性的体内选择系统
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摘要
The present invention provides in vivo systems in which activity of a biological cleavage enzyme, such as a site-specific recombinase, a homing endonuclease, or an intein, is linked to cell viability and therefore can be selected. The invention further provides methods of making cells in which the activity of a biological cleavage enzyme is linked to viability, as well as methods of identifying new biological cleavage enzymes, including enzymes having altered site specificity, using such cells.
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