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Process for synthesizing oil and surfactant-free hyaluronic acid nanoparticles and microparticles
Process for synthesizing oil and surfactant-free hyaluronic acid nanoparticles and microparticles
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机译:不含油和表面活性剂的透明质酸纳米粒子和微粒的合成方法
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摘要
A method for synthesizing uniformly sized hyaluronic acid (“HA”) particles that are substantially free from oil and surfactant contaminants. The method comprises crosslinking HA chains with 1-ethyl-3-(3-dimethlyaminopropyl) carbodiimide hydrochloride (“EDAC”) and adipic acid dihydrazide in a water/acetone mixture.
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