Method for the use of ¹¹C carbon monoxide in labeling synthesis of ¹¹C-labelled amides using metal amides and photo-induced free radical carbonylation

摘要

Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.