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Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
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机译:康他汀A-4前体药物及其反式异构体的合成
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摘要
Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugs”.
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