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Anti-Cancer Drug Design

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中文名称：抗癌药物设计

ISSN：0266-9536
出版周期：Quarterly

发文量：165

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1.Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins.

机译：双齿氮芥的双（二烷基）二硫代氨基甲酸钴（III）配合物：合成，还原化学和生物学评估作为缺氧选择性细胞毒素。
- 作者：Ware DC;Palmer HR;Pruijn FB;Anderson RF;Brothers PJ;Denny WA;Wilson WR
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第2期
- Antineoplastic Agents;
- Cobalt;
- Nitrogen Mustard Compounds;
- Carbamates;
- 抗肿瘤药;
- 钴;
- 氮芥化合物;
2.Targeting hypoxia with a new generation of indolequinones.

机译：用新一代的吲哚醌靶向低氧。
- 作者：Jaffar M;Naylor MA;Robertson N;Stratford IJ
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第6期
- Antineoplastic Agents;
- Cell Hypoxia;
- Indoles;
- Quinones;
- Oxidoreductases;
- 抗肿瘤药;
- 细胞低氧;
- 吲哚类;
- 醌类;
3.Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols.

机译：2-（芳基甲基氨基）-1,3-丙二醇的细胞毒性与蛋白质相关的DNA链断裂的相关性。
- 作者：Dorr RT;zcc.arizona.edu;Bellamy W;Liddil JD;Baker A;Bair KW
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第7期
- Antineoplastic Agents;
- DNA Damage;
- DNA Topoisomerase ATP Hydrolysing antagonists and inhibitors;
- 抗肿瘤药;
- DNA损伤;
- 酶抑制剂;
- 嵌入剂;
4.Synthesis, cancericidal and antimicrotubule activities of 3-(haloacetamido)-benzoylureas.

机译：3-（卤代乙酰胺基）-苯甲酰脲的合成，抗癌和抗微管活性。
- 作者：Jiang JD;Roboz J;Weisz I;Deng L;Ma L;Holland JF;Bekesi JG
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第7期
- Antineoplastic Agents;
- Microtubules;
- Urea;
- 抗肿瘤药;
- 微管;
5.Synthesis of self-immolative glucuronide-based prodrugs of a phenol mustard.

机译：酚芥子油自焚葡萄糖醛酸酯类前药的合成。
- 作者：Lougerstay-Madec R;Florent JC;Monneret C;Nemati F;Poupon MF
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第8期
- Antineoplastic Agents;
- Glucuronates;
- Mustard Compounds;
- Phenols;
- Prodrugs;
- 抗肿瘤药;
- 葡糖醛酸类;
- 芥子化合物;
- 酚类;
- 药物前体;
6.Antitumor activity of paclitaxel-2'-glycinate conjugated to poly(ethylene glycol): a water-soluble prodrug.

机译：与聚乙二醇偶联的紫杉醇2'-甘氨酸盐的抗肿瘤活性：水溶性前药。
- 作者：Pendri A;Conover CD;Greenwald RB
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第5期
- Antineoplastic Agents;
- Phytogenic;
- Paclitaxel;
- Polyethylene Glycols;
- Prodrugs;
- 抗肿瘤药;
- 植物;
- 紫杉酚;
- 聚乙烯二醇类;
- 药物前体;
7.Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines.

机译：秋水仙碱类似物对MDR阳性和MDR阴性的人类癌细胞系的抗增殖活性。
- 作者：De-Vincenzo R;Scambia G;Ferlini C;Distefano M;Filippini P;Riva A;Bombardelli E;Pocar D;Gelmi ML;Benedetti-Panici P;Mancuso S
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第1期
- Antineoplastic Agents;
- Colchicine;
- Drug Resistance;
- Multiple;
- Growth Inhibitors;
- 抗肿瘤药;
- 秋水仙碱;
- 抗药性;
- 多药;
- 生长抑制物;
8.Uptake of a boronated epidermal growth factor-dextran conjugate in CHO xenografts with and without human EGF-receptor expression.

机译：在有和没有人EGF受体表达的CHO异种移植物中摄取硼化的表皮生长因子-葡聚糖缀合物。
- 作者：Olsson P ms.uu.se;Gedda L;Goike H;Liu L;Collins VP;Ponten J;Carlsson J
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第4期
- Boron;
- Neoplasms;
- Experimental;
- Receptor;
- Epidermal Growth Factor metabolism;
- 硼;
- 肿瘤;
- 实验性;
9.5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione)prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro.

机译：3-羟甲基-5-氮丙啶基-1-甲基-2-（1H-吲哚-4,7-二酮）丙-2-烯-1-醇的5-取代类似物（EO9，NSC 382459）和它们的区域异构体-选择剂：体外结构细胞毒性。
- 作者：Jaffar M;Naylor MA;Robertson N;Lockyer SD;Phillips RM;Everett SA;Adams GE;Stratford IJ
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第2期
- Antineoplastic Agents;
- Aziridines;
- Indoles;
- NAD(P)H Dehydrogenase-(Quinone);
- 抗肿瘤药;
- 氮丙啶类;
- 吲哚类;
10.Synthesis and antiproliferative properties of 4-aminoquinazoline derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity.

机译：4-氨基喹唑啉衍生物作为EGF受体相关酪氨酸激酶活性抑制剂的合成及其抗增殖特性。
- 作者：Bouey-Bencteux E;Loison C;Pommery N;Houssin R;Henichart JP
- 期刊名称：《Anti-Cancer Drug Design》 | 1998年第8期
11.Camptothecin delivery systems: the utility of amino acid spacers for the conjugation of camptothecin with polyethylene glycol to create prodrugs.

机译：喜树碱递送系统：氨基酸间隔基用于喜树碱与聚乙二醇缀合以产生前药的用途。
- 作者：Conover CD;Greenwald RB;Pendri A;Shum KL
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第6期
- Antineoplastic Agents;
- Phytogenic;
- Camptothecin;
- Prodrugs;
- Polyethylene Glycols;
- 抗肿瘤药;
- 植物;
- 喜树碱;
- 药物前体;
12.5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.

机译：混合拓扑异构酶I / II的5,7-二取代类似物会毒化N-（2-（二甲基氨基）乙基）ac啶-4-羧酰胺（DACA）：DNA结合和细胞毒性模式。
- 作者：Spicer JA;Finlay GJ;Baguley BC;Velea L;Graves DE;Denny WA
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第1期
- Acridines;
- DNA Topoisomerase;
- DNA Topoisomerase ATP Hydrolysing antagonists and inhibitors;
- 吖啶类;
- DNA拓扑异构酶;
- DNA;
- 肿瘤;
- 酶抑制剂;
- 嵌入剂;
13.Cytotoxicity and DNA binding mode of new platinum-iminoether derivatives with different configuration at the iminoether ligands.

机译：在亚氨基醚配体上具有不同构型的新铂-亚氨基醚衍生物的细胞毒性和DNA结合模式。
- 作者：Boccarelli A;Coluccia M;Intini FP;Natile G;Locker D;Leng M
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Antineoplastic Agents;
- DNA;
- Neoplasm;
- Organoplatinum Compounds;
- dichlorobis(ethyl iminoacetate)platinum(II);
- 抗肿瘤药;
- DNA;
- 肿瘤;
- 有机铂化合物;
14.Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos.

机译：端粒相互作用剂会影响海胆胚胎的增殖速率并引起染色体不稳定。
- 作者：Izbicka E;Nishioka D;Marcell V;Raymond E;Davidson KK;Lawrence RA;Wheelhouse RT;Hurley LH;Wu RS;Von Hoff-DD
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第4期
- Chromosomes;
- Enzyme Inhibitors;
- Porphyrins;
- Sea Urchins;
- Telomerase;
- Telomere;
- 染色体;
- 酶抑制剂;
- 卟啉类;
- 海胆;
- 端粒;
- 末端转移酶;
- 端粒;
15.Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

机译：用于抗体和基因指导的酶前药治疗的前药（ADEPT和GDEPT）。
- 作者：Niculescu Duvaz-I;Friedlos F;Niculescu Duvaz-D;Davies L;Springer CJ
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第6期
- Gene Therapy;
- Immunotherapy;
- Neoplasms;
- Prodrugs;
- Antibodies;
- Neoplasm;
- 基因疗法;
- 免疫疗法;
- 肿瘤;
- 药物前体;
16.The development of telomerase inhibitors: the G-quartet approach.

机译：端粒酶抑制剂的开发：G四方法。
- 作者：Mergny JL;Mailliet P;Lavelle F;Riou JF;Laoui A;Helene C
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第4期
- Enzyme Inhibitors;
- Telomerase;
- Oligonucleotides;
- Antisense;
- RNA;
- Antisense;
- 酶抑制剂;
- 端粒;
- 末端转移酶;
17.Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.

机译：硝氮N-氧化物：侧链N-氧化物的性质变化对缺氧选择性细胞毒性的影响。
- 作者：Lee HH;Wilson WR;Denny WA
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第6期
- Antineoplastic Agents;
- Cell Hypoxia;
- Nitracrine;
- Indicators and Reagents;
- 抗肿瘤药;
- 细胞低氧;
- 硝氨丙吖啶;
18.Sequence specificity and reactivity of the binding of phenazine-tethered platinum complexes to DNA.

机译：吩嗪系铂配合物与DNA结合的序列特异性和反应性。
- 作者：Perrin LC;Cullinane C;McFadyen WD;Phillips DR
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Antineoplastic Agents;
- DNA;
- Organoplatinum Compounds;
- Phenazines;
- DNA Directed RNA Polymerase;
- 抗肿瘤药;
- 有机铂化合物;
- 吩嗪类;
19.Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level.

机译：通过药物干预在转录水平上实现基因表达控制的分子方法。
- 作者：Zewail Foote-M;Hurley LH
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第1期
- Antineoplastic Agents;
- Drug Design;
- DNA;
- Neoplasm;
- Gene Expression Regulation;
- 抗肿瘤药;
- 药物设计;
- DNA;
- 肿瘤;
- 基因表达调控;
- 转录;
- 遗传;
20.Bis-benzimidazole anticancer agents: targeting human tumour helicases.

机译：双苯并咪唑抗癌药：靶向人肿瘤解旋酶。
- 作者：Soderlind KJ;Gorodetsky B;Singh AK;Bachur NR;Miller GG;Lown JW
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第1期
- Antineoplastic Agents;
- Benzimidazoles;
- DNA Helicases;
- DNA;
- Neoplasm;
- DNA Restriction Enzymes;
- 抗肿瘤药;
- 苯咪唑类;
- DNA螺旋酶类;
- DNA;
- 肿瘤;
21.Cellular uptake of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA).

机译：N-（2-（二甲基氨基）乙基）ac啶-4-羧酰胺（DACA）的细胞摄取。
- 作者：Haldane A;Finlay GJ;Hay MP;Denny WA;Baguley BC
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Acridines;
- Antineoplastic Agents;
- Enzyme Inhibitors;
- Intercalating Agents;
- 吖啶类;
- 抗肿瘤药;
- 酶抑制剂;
- 嵌入剂;
22.Dimeric analogues of non-cationic tricyclic aromatic carboxamides are a new class of cytotoxic agents.

机译：非阳离子三环芳族羧酰胺的二聚体类似物是一类新的细胞毒性剂。
- 作者：Spicer JA;Gamage SA;Atwell GJ;Finlay GJ;Baguley BC;Denny WA
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Amides;
- Antineoplastic Agents;
- Growth Inhibitors;
- Heterocyclic Compounds;
- 2-Ring;
- 酰胺类;
- 抗肿瘤药;
- 生长抑制物;
- 杂环化合物;
- 2环;
23.Recent progress in P-glycoprotein research.

机译：P-糖蛋白研究的最新进展。
- 作者：Ueda K;Yoshida A;Amachi T
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Drug Resistance;
- Multiple;
- Drug Resistance;
- Neoplasm;
- P-Glycoprotein;
- 抗药性;
- 多药;
- 抗药性;
- 肿瘤;
- P-糖蛋白;
24.DNA sequence recognition by a novel series of minor groove-binding ligands.

机译：DNA序列识别的一系列新颖的小沟结合配体。
- 作者：Fox KR;Yan Y;Gong B
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Base Sequence;
- DNA;
- Deoxyribonuclease I;
- Benzene Derivatives;
- Ligands;
- Plasmids;
- 碱基序列;
25.Antitumour imidazotetrazines. Part 37. Conjugation of the DNA major-groove alkylating imidazotetrazine mitozolomide to peptide motifs recognizing the minor groove.

机译：抗肿瘤咪唑并四嗪类。第37部分。DNA大沟烷基化咪唑并四氮杂咪唑胺与识别小沟的肽基序的结合。
- 作者：Arrowsmith J;Missailidis S;Stevens MF
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Antineoplastic Agents;
- Alkylating;
- DNA;
- DNA-Binding Proteins;
- Nitrogen Mustard Compounds;
- 抗肿瘤药;
- 烷基化;
- DNA结合蛋白质类;
- 氮芥化合物;
- 寡肽类;
26.Design, synthesis and evaluation of human telomerase inhibitors based upon a tetracyclic structural motif.

机译：基于四环结构基序的人类端粒酶抑制剂的设计，合成和评估。
- 作者：Perry PJ;Gowan SM;Read MA;Kelland LR;Neidle S
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第4期
- Drug Design;
- Enzyme Inhibitors;
- Telomerase;
- Taq Polymerase;
- 药物设计;
- 酶抑制剂;
- 端粒;
- 末端转移酶;
27.Porphyrins can catalyze the interconversion of DNA quadruplex structural types.

机译：卟啉可以催化DNA四链体结构类型的相互转化。
- 作者：Arthanari H;Bolton PH
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第4期
- DNA;
- Porphyrins;
- 卟啉类;
28.Drug resistance mediated by cellular stress response to the microenvironment of solid tumors.

机译：细胞应激对实体瘤微环境介导的耐药性。
- 作者：Tomida A;Tsuruo T
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Drug Resistance;
- Neoplasm;
- Neoplasms;
- Antineoplastic Agents;
- Glucose;
- 抗药性;
- 肿瘤;
- 肿瘤;
29.Structural and functional analysis of the control region of the human DNA topoisomerase II alpha gene in drug-resistant cells.

机译：耐药细胞中人类DNA拓扑异构酶II alpha基因控制区的结构和功能分析。
- 作者：Takano H;Ise T;Nomoto M;Kato K;Murakami T;Ohmori H;Imamura T;Nagatani G;Okamoto T;Ohta R;Furukawa M;Shibao K;Izumi H;Kuwano M;Kohno K
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Drug Resistance;
- Neoplasm;
- DNA Topoisomerase ATP Hydrolysing genetics;
- Isoenzymes;
- 抗药性;
- 肿瘤;
- 同工酶类;
30.Accurate determination of quadruplex binding affinity and potency of G-quadruplex-interactive telomerase inhibitors by use of a telomerase extension assay requires varying the primer concentration.

机译：通过使用端粒酶延伸测定法准确测定G-四链体相互作用的端粒酶抑制剂的四链体结合亲和力和效力需要改变引物浓度。
- 作者：Cathers BE;Sun D;Hurley LH
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第4期
- Anthraquinones;
- Enzyme Inhibitors;
- Telomerase;
- BSU-1051;
- Guanine;
- 蒽醌类;
- 酶抑制剂;
- 端粒;
- 末端转移酶;
31.Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards.

机译：DNA靶向的4-苯胺基喹啉苯胺芥菜的序列选择性，交联效率和细胞毒性。
- 作者：McClean S;Costelloe C;Denny WA;Searcey M;Wakelin LP
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Aniline Mustard;
- Antineoplastic Agents;
- Alkylating;
- DNA;
- Antiviral Agents;
- 苯胺氮芥;
- 抗肿瘤药;
- 烷基化;
32.A comparative cell-based high throughput screening strategy for the discovery of selective tyrosine kinase inhibitors with anticancer activity.

机译：一种基于细胞的比较高通量筛选策略，用于发现具有抗癌活性的选择性酪氨酸激酶抑制剂。
- 作者：Stratowa C;Baum A;Castanon MJ;Dahmann G;Himmelsbach F;Himmler A;Loeber G;Metz T;Schnitzer R;Solca F;Spevak W;Tontsch U;von Ruden-T
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第5期
33.Structure-based design of potent inhibitors of EGF-receptor tyrosine kinase as anti-cancer agents.

机译：基于结构的EGF受体酪氨酸激酶有效抑制剂作为抗癌药的设计。
- 作者：Ghosh S;Narla RK;Zheng Y;Liu XP;Jun X;Mao C;Sudbeck EA;Uckun FM
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第5期
- Antineoplastic Agents;
- Enzyme Inhibitors;
- Receptor;
- Epidermal Growth Factor antagonists and inhibitors;
- 抗肿瘤药;
- 酶抑制剂;
34.Resistance to cisplatin.

机译：耐顺铂。
- 作者：Akiyama S;Chen ZS;Sumizawa T;Furukawa T
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Antineoplastic Agents;
- Cisplatin;
- Neoplasms;
- 抗肿瘤药;
- 顺铂;
- 肿瘤;
35.Cytoskeletons and antimitotic agents developed in Japan.

机译：日本开发了细胞骨架和抗有丝分裂剂。
- 作者：Nishio K;Saijo N
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Antineoplastic Agents;
- Cytoskeleton;
- Microtubule-Associated Proteins;
- Tubulin;
- 抗肿瘤药;
- 细胞支架;
36.Multidrug resistance-associated protein subfamily transporters and drug resistance.

机译：多药耐药相关蛋白亚家族转运蛋白和耐药性。
- 作者：Kuwano M;Toh S;Uchiumi T;Takano H;Kohno K;Wada M
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- ABC Transporters;
- Carrier Proteins;
- Drug Resistance;
- Neoplasm;
- Genes;
- MDR;
- ABC转运子;
- 载体蛋白质类;
- 抗药性;
- 肿瘤;
- 基因;
- MDR;
37.Relationships between topoisomerase II inhibition, sequence-specificity and DNA binding mode of dicationic diphenylfuran derivatives.

机译：二磷酸呋喃衍生物的拓扑异构酶II抑制，序列特异性与DNA结合模式之间的关系。
- 作者：Bailly C;Dassonneville L;Carrasco C;Lucas D;Kumar A;Boykin DW;Wilson WD
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第1期
38.Antitumour prodrug development using cytochrome P450 (CYP) mediated activation.

机译：使用细胞色素P450（CYP）介导的激活作用开发抗肿瘤前药。
- 作者：Patterson LH;McKeown SR;Robson T;Gallagher R;Raleigh SM;Orr S
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第6期
- Antineoplastic Agents;
- Cytochrome P-450;
- Neoplasms;
- Prodrugs;
- 抗肿瘤药;
- 细胞色素P-450;
- 肿瘤;
- 药物前体;
39.Telomerase as an anti-cancer drug target: will it fulfil its early promise?

机译：端粒酶作为抗癌药物的靶点：它将履行其早期承诺吗？
- 作者：Newbold RF
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第4期
- Antineoplastic Agents;
- Enzyme Inhibitors;
- Telomerase;
- Protein p53;
- 抗肿瘤药;
- 酶抑制剂;
- 端粒;
- 末端转移酶;
40.Binding of bis-substituted 2-aza-anthracenedione regioisomers to DNA: effects of the relative positioning of the side chains.

机译：双取代的2-氮杂-蒽二酮区域异构体与DNA的结合：侧链的相对位置的影响。
- 作者：Sissi C;Moro S;Zagotto G;Ellis M;Krapcho AP;Menta E;Palumbo M
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Anthraquinones;
- DNA;
- DNA Topoisomerase-(ATP Hydrolysing);
- Aza Compounds;
- 蒽醌类;
41.The quinobenzoxazines: relationship between DNA binding and biological activity.

机译：喹苯并恶嗪：DNA结合与生物活性之间的关系。
- 作者：Kwok Y;Sun D;Clement JJ;Hurley LH
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第5期
- Antineoplastic Agents;
- DNA;
- Oxazines;
- 抗肿瘤药;
- 恶嗪类;
42.Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy.

机译：ADEPT策略在癌症化疗中耐多药耐药性中的应用。
- 作者：Desbene S;Van HD;Michel S;Tillequin F;Koch M;Schmidt F;Florent JC;Monneret C;Straub R;Czech J;Gerken M;Bosslet K
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Antineoplastic Agents;
- Prodrugs;
- Glucuronidase;
- Glucuronates;
- Quinine;
- Doxorubicin;
- 抗肿瘤药;
- 药物前体;
43.Virus-directed enzyme prodrug therapy using CB1954.

机译：使用CB1954的病毒指导的酶前药治疗。
- 作者：Grove JI;Searle PF;Weedon SJ;Green NK;McNeish IA;Kerr DJ
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第6期
- Alkylating Agents;
- Antineoplastic Agents;
- Alkylating;
- Aziridines;
- Gene Therapy;
- 烷化剂;
- 抗肿瘤药;
- 烷基化;
- 氮丙啶类;
- 基因疗法;
- 遗传载体;
- 药物前体;
- 病毒;
44.Influence of p53 mutation on pathological grade, but not prognosis of non-Hodgkin's lymphoma.

机译：p53突变对非霍奇金淋巴瘤病理分级的影响，但对预后没有影响。
- 作者：Osada M;Ishioka C;Ichinohasama R;Kadowaki I;Murakawa Y;Watanabe M;Kanamaru R;Ikawa S
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Genes;
- p53;
- Lymphoma;
- Non Hodgkin genetics;
- Lymphoma;
- Non Hodgkin pathology;
- 基因;
- P53;
45.Recognition elements that determine affinity and sequence-specific binding to DNA of 2QN, a biosynthetic bis-quinoline analogue of echinomycin.

机译：确定与2QN DNA的亲和力和序列特异性结合的识别元件，2QN是棘皮霉素的生物合成双喹啉类似物。
- 作者：Bailly C;Echepare S;Gago F;Waring MJ
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Antibiotics;
- DNA;
- Echinomycin;
- Deoxyribonuclease I;
- 2QN echinomycin;
- 抗生素类;
- 棘霉素;
46.Intensely cytotoxic anthracycline prodrugs: galactosides.

机译：强烈的细胞毒性蒽环类前药：半乳糖苷。
- 作者：Bakina E;Farquhar D
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第6期
- Antibiotics;
- Anthracycline;
- Antibiotics;
- Antineoplastic;
- Galactosides;
- Prodrugs;
- 抗生素类;
- 蒽环;
- 抗生素类;
- 抗肿瘤;
- 半乳糖苷类;
- 药物前体;
47.Synthesis and antitumor activities of amino acid prodrugs of amino-combretastatins.

机译：氨基combretastatins氨基酸前药的合成和抗肿瘤活性。
- 作者：Ohsumi K;Hatanaka T;Nakagawa R;Fukuda Y;Morinaga Y;Suga Y;Nihei Y;Ohishi K;Akiyama Y;Tsuji T
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第6期
- Antineoplastic Agents;
- Bibenzyls;
- Prodrugs;
- 抗肿瘤药;
- 联苄类;
- 药物前体;
48.Adhesion-dependent multicellular drug resistance.

机译：粘附依赖性多细胞耐药性。
- 作者：Green SK;Frankel A;Kerbel RS
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第2期
- Cell Adhesion;
- Drug Resistance;
- Neoplasm;
- 细胞粘附;
- 抗药性;
- 肿瘤;
49.The design of cobalt(III) complexes of phenazine-1-carboxamides as prointercalators and potential hypoxia-selective cytotoxins.

机译：吩嗪-1-羧酰胺钴（III）配合物的设计以及潜在的缺氧选择性细胞毒素。
- 作者：Perrin LC;Wilson WR;Denny WA;McFadyen WD
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第3期
- Antineoplastic Agents;
- Cobalt;
- Intercalating Agents;
- Organometallic Compounds;
- 抗肿瘤药;
- 钴;
- 嵌入剂;
- 有机金属化合物;
- 吩嗪类;
50.Blockade of telomerase function in various cells.

机译：端粒酶的阻断作用在各种细胞中。
- 作者：Yegorov YE;Akimov SS;Akhmalisheva AK;Semenova IV;Smirnova YB;Kraevsky AA;Zelenin AV
- 期刊名称：《Anti-Cancer Drug Design》 | 1999年第4期
- Enzyme Inhibitors;
- Telomerase;
- 酶抑制剂;
- 端粒;
- 末端转移酶;
51.Role of DNA minor groove alkylation and DNA cross-linking in the cytotoxicity of polybenzamide mustards.

机译：DNA小沟烷基化和DNA交联在聚苯甲酰胺芥菜的细胞毒性中的作用。
- 作者：Turner PR;Denny WA;Ferguson LR
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第4期
- Antineoplastic Agents;
- Alkylating;
- Benzamides;
- Cross-Linking Reagents;
- DNA;
- 抗肿瘤药;
- 烷基化;
- 苯甲酰胺类;
- 交联试剂;
- 氮芥化合物;
52.Inhibition of N-linked glycosylation down-regulates insulin-like growth factor-1 receptor at the cell surface and kills Ewing's sarcoma cells: therapeutic implications.

机译：N-联糖基化的抑制下调细胞表面的胰岛素样生长因子-1受体并杀死尤因氏肉瘤细胞：治疗意义。
- 作者：Girnita L;Wang M;Xie Y;Nilsson G;Dricu A;Wejde J;Larsson O
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第1期
- Antineoplastic Agents;
- Down Regulation Physiology;
- Receptor;
- IGF Type 1 antagonists and inhibitors;
- 抗肿瘤药;
- 肉瘤;
- Ewing;
53.Site-directed irreversible inhibitors of the erbB family of receptor tyrosine kinases as novel chemotherapeutic agents for cancer.

机译：受体酪氨酸激酶erbB家族的定点不可逆抑制剂，是新型的癌症化疗药物。
- 作者：Fry DW
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第1期
- Antineoplastic Agents;
- Enzyme Inhibitors;
- Neoplasms;
- Receptor;
- Epidermal Growth Factor antagonists and inhibitors;
- 抗肿瘤药;
- 酶抑制剂;
- 肿瘤;
54.Design, synthesis and antitumor cytotoxicity of novel bis-benzimidazoles.

机译：新型双苯并咪唑的设计，合成和抗肿瘤细胞毒性。
- 作者：Singh AK;Lown JW
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第4期
- Antineoplastic Agents;
- Alkylating;
- Benzimidazoles;
- Growth Inhibitors;
- 抗肿瘤药;
- 烷基化;
- 苯咪唑类;
55.Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity.

机译：设计两种依托泊苷-amsacrine缀合物：拓扑异构酶II和微管蛋白聚合抑制作用以及与细胞毒性的关系。
- 作者：Arimondo P;Boukarim C;Bailly C;Dauzonne D;Monneret C
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第6期
- Etoposide;
- Amsacrine;
- Polymerization;
- Psychological inhibition;
- Cytotoxicity;
- 依托泊甙;
- 安吖啶;
- 微管蛋白;
56.Synthesis of new homochiral bispyrrolidines as potential DNA cross-linking antitumour agents.

机译：合成新的高手性双吡咯烷类化合物作为潜在的DNA交联抗肿瘤剂。
- 作者：Anderson FM;OHare CC;Hartley JA;Robins DJ
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第2期
- Antineoplastic Agents;
- Cell Survival;
- Cross-Linking Reagents;
- DNA;
- Pyrrolidines;
- 抗肿瘤药;
- 细胞存活;
- 交联试剂;
- 吡咯烷类;
57.Biological properties of 5,11-dimethyl-6H-pyrido(3,2-b)carbazoles: a new class of potent antitumour drugs.

机译：5,11-二甲基-6H-吡啶并（3,2-b）咔唑的生物学性质：一类新型的有效抗肿瘤药物。
- 作者：Moinet Hedin-V;Tabka T;Poulain L;Godard T;Lechevrel M;Saturnino C;Lancelot JC;Le Talaer-JY;Gauduchon P
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第2期
- Antineoplastic Agents;
- Cell Survival;
- DNA Damage;
- Ellipticines;
- ellipticine;
- 抗肿瘤药;
- 细胞存活;
- DNA损伤;
- 玖瑰树碱类;
58.Tetramethylpiperidine-substitution increases the antitumor activity of the riminophenazines for an acquired multidrug-resistant cell line.

机译：四甲基哌啶取代增加了对获得多药耐药细胞系的riminophenazines的抗肿瘤活性。
- 作者：van-Rensburg CE;Joone GK;OSullivan JF
- 期刊名称：《Anti-Cancer Drug Design》 | 2000年第4期
- Antineoplastic Agents;
- Drug Resistance;
- Multiple;
- Phenazines;
- Antineoplastic Agents;
- Phytogenic;
- 抗肿瘤药;
- 抗药性;
- 多药;
- 吩嗪类;
59.Cell-based screening approach for antitumor drug leads which exploits sensitivity differences between normal and cancer cells: identification of two novel cell-cycle inhibitors.

机译：基于细胞的抗肿瘤药物前导筛选方法，该方法利用了正常细胞与癌细胞之间的敏感性差异：两种新型细胞周期抑制剂的鉴定。
- 作者：Vassilev LT;Kazmer S;Marks IM;Pezzoni G;Sala F;Mischke SG;Foley L;Berthel SJ
- 期刊名称：《Anti-Cancer Drug Design》 | 2001年第1期
- Antineoplastic Agents;
- Cell Cycle;
- Drug Screening Assays;
- Antitumor;
- Neoplasms;
- 抗肿瘤药;
- 细胞周期;
- 药物筛选试验;
- 抗肿瘤;
- 肿瘤;
60.A novel B-ring modified homocamptothecin, 12-Cl-hCPT, showing antiproliferative and topoisomerase I inhibitory activities superior to SN-38.

机译：一种新型的B环修饰的高喜树碱12-Cl-hCPT，显示出优于SN-38的抗增殖和拓扑异构酶I抑制活性。
- 作者：Bailly C;Laine W;Baldeyrou B;Demarquay D;Huchet M;Coulomb H;Lanco C;Lavergne O;Bigg DC
- 期刊名称：《Anti-Cancer Drug Design》 | 2001年第1期
- Antineoplastic Agents;
- Antineoplastic Agents;
- Phytogenic;
- Camptothecin;
- DNA Topoisomerases;
- Type I antagonists and inhibitors;
- 抗肿瘤药;
- 抗肿瘤药;
- 植物;
- 喜树碱;
- 酶抑制剂;
61.Ethyl side-chain modifications in novel flexible antiestrogens--design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line.

机译：新型柔性抗雌激素的乙基侧链修饰-抗MCF-7乳腺肿瘤细胞系的设计，合成和生物学功效。
- 作者：Meegan MJ;Hughes RB;Lloyd DG;Williams DC;Zisterer DM
- 期刊名称：《Anti-Cancer Drug Design》 | 2001年第1期
- Antineoplastic Agents;
- Hormonal;
- Breast Neoplasms;
- Estrogen Antagonists;
- 抗肿瘤药;
- 激素;
- 乳腺肿瘤;
- 雌激素拮抗剂;
62.Cancerostatic octadecylpiperidinoylphosphate liposomes: effect of composition on uptake by and toxicity to J774 mouse macrophage cells and MT1 breast cancer cells in vitro.

机译：抗癌的十八烷基哌啶子基磷酸酯脂质体：该组合物对体外J774小鼠巨噬细胞和MT1乳腺癌细胞摄取和毒性的影响。
- 作者：Zeisig R;Stahn R;Teppke AD;Arndt D
- 期刊名称：《Anti-Cancer Drug Design》 | 2001年第1期
- Antineoplastic Agents;
- Macrophages;
- Phospholipids;
- 抗肿瘤药;
- 巨噬细胞;
- 磷脂类;
63.Synthesis and anti-melanoma activity of analogues of N-acetyl-4-S-cysteaminylphenol substituted with two methyl groups alpha to the nitrogen.

机译：氮上两个甲基取代的N-乙酰基-4-S-半胱氨酰苯酚类似物的合成和抗黑色素瘤活性。
- 作者：Lant NJ;McKeown P;Timoney MC;Kelland LR;Rogers PM;Robins DJ
- 期刊名称：《Anti-Cancer Drug Design》 | 2001年第1期
- Antineoplastic Agents;
- Cysteamine;
- Melanoma;
- Experimental;
- Phenols;
- 抗肿瘤药;
- 半胱胺;
- 黑色素瘤;
- 实验性;
- 酚类;
64.Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type.

机译：高效哌啶二酮类芳香化酶抑制剂的合成，评估和QSAR研究。
- 作者：Baston E;Klein CD;Grimminger W;Hebecker N;Hartmann RW
- 期刊名称：《Anti-Cancer Drug Design》 | 2001年第1期
- Aromatase;
- Enzyme Inhibitors;
- Piperidines;
- 芳香酶;
- 酶抑制剂;
- 哌啶类;
65.A prodrug approach to the design of cRaf1 kinase inhibitors with improved cellular activity.

机译：设计具有改善的细胞活性的cRaf1激酶抑制剂的前药方法。
- 作者：Wood E;Crosby RM;Dickerson S;Frye SV;Griffin R;Hunter R;Jung DK;McDonald OB;McNutt R;Mahony WB;Peel MR;Ray J;Lackey K
- 期刊名称：《Anti-Cancer Drug Design》 | 2001年第1期
- Antineoplastic Agents;
- Drug Design;
- Enzyme Inhibitors;
- Prodrugs;
- Proteins;
- 抗肿瘤药;
- 药物设计;
- 酶抑制剂;
- 药物前体;
- 蛋白质类;
- 原癌基因蛋白质c-caf类;

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