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Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5
Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5
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机译:源自抗HIV-1 gp120抗体的多肽,可消除gp120与CCR5的结合
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摘要
The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition, the invention is directed to a method for increasing the affinity of antibodies for their antigens by sulfating tyrosine residues in the antibody amino acid chain.
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