Hydration of the mucosa and mucosal clearance increased by Treatment with sodium channel bloquadores and osmolytes

摘要

N for the formation of 1,3-diazo or 1,3-cyclodiazo-or nitrous oxide-or sulfur dioxide, or sulfur dioxide, or - O - (CH2) m-nr10-ch2 (method and composition for the treatment of diseases improved by purification and hydrate (chr8) n-ch2or8), provided that at least two ch2or8 groups are adjacent to the added binder and managed by An S and R8 group are combined to form a 1.3 effective amount of sodium blocker and an osmolito object, which need to be purified - diazo-1.3-cyclodiazo - or the adhesive solution of adhesive and reinforcement adhesive, and each R5 can also be independent. Item 14: one component,Purchase (a) n-repr (chor8) n-extra, connector - (CH2) n (chor8) n-extra, connector - (CH2CH2O) m-ch2-extra, represented by formula (1), halogenated connector - (CH2CH2O) m-ch2ch2-end, connector - (CH2, trifluoroalkyl, low, ILO n -) N-G, end, There is one type of - (N18), nn18 - (N18 - (N18) has monohydroxybenzeneNR2 (NR2 (or CH2) m-extreme, connector - (CH2) M-C (= O) nr11r11, Cqilo low; R2, R3 and R4 are as defined in (1) below - (CH2) M-C (= O) nr12r12, connector - (CH2) n - (z) G-N en,(2)(3)(4)(5)(6)(7)(8) or (9): (1) each R2 is, independently (CH2) m- (Z) g-EXTREME, connector-Zg- (CH2) m-Het- (CH2) m-EXTREME; Each connector is independently -Ote, -R7, - (CH2) m-OR8, - (CH2) m- NR7R10, - (CH2) n (CHO-,- (CH2) n--O (CH2) m--NR13-C (3DO) -NR13 -NR13-C (R8) (CHOR8) n-CH2OR8 - (CH2CH2O) m-R8 - (CH2CH2O) m-CH2CH2NR7R10 - (CH2) nC (3DO) NR7R10 - (CH2) n -C (3DO) NR13- (CH2) m - (CH2) n-Zg- (CH2) n -S--So...-SO2...-SO2NR7...-SO2N10-O-HET-(CCH2) m-nr10-ch2 (chr8) (chr8) n-ch2or8, - (CH2) n-co2r7, or as formula (2);Each R3 and R4 is an inseparable extremely unpunished endosulfan, dioxin, isopropenylhydrazide, isopropyl (= O) nr13r13, isobutylene, h, composed of formeroril-w, CN, O-C (= s) nr13r13, zgr13, CR10 (zgrla (3),1. Lower alkyl, lower alkyl, phenyl, phenyl low alkyl (halophenyl) - alqu13 (zgr13),-C (3DO) OAr -C (3DO) NR13Ar imidazolina ilo inferior (alquilfenilalquil) -inferior (alcoxtetrazol tetrazol amida -SO2NHR13 -SO2NH-C (R13Rifenil) inferior-alquilo inferior naftil-alquilo i13) - (Z) g-R13 un cada Ar es independientemente fenilo fenilo sustituido donde los sustituyentes del feno representado por la formula (3) donde cada RL esilo sustituido son 1-3 sustituyentes independiente independientemente -R7 - (CH2) n-OR8 -O- (CH2) m-Omente seleccionados -ZgR13 -CR10 (ZgR13) (ZgR13)-C (3DO) OAr -C (3DO) NR13Ar imidazolina tetrazol tetrazol amida -S -O- (CH2) m- (Z) g-R7 - (CH2) n-NR10-CH2 (CHOR8) (CHOR8O2NHR13 -SO2NH-C a. Design (7) or (8) for each or every cycle;each R6 is independently R5 -R7, -OR8, -N (R7) 2, - (CH2) m-OR8, -Os, independently, an integer from 0 to 10 ;-( CH2) m-OR8, - (CH2) n-NR7R10, -O- (CH2) m-NR7R10, (CH each p is an integer from 0 to 10; with cond2) n (CHOR8) (CHOR8) n-CH2OR8, -O- (CH2 ) m (CHOR8) (CHOR8) icion that the sum of oyp in each chain continues-CH2OR8, - (CH2CH2O) m-R8, -O- (CH2CH2O) m-R8, - (CH2gua is 1 to 10; each x is, independently, OCH2O) m-CH2CH2NR7R10, -O- (CH2CH2O) m-CH2CH2NR7R10, -,10th, C (= O),CHOH C (3DN-R10)CHNR7R10 o repres (CH2) nC (3DO) NR7R10 -O- (CH2) mC (3DO) NR7R10 - (CH2) nenta un enlace simple cada R6 es independienteme- (Z) g-R7 -O- (CH2) m- ( O - (nn7 - (XO) 2 - (NNR 2 - (XO) 2 - (XO) 2 - (nnnr 2r7) - (CH2) n-nr10-ch2 (chr8) (single cycle) or discipline, each R7 is, N-ch2or8, - O - (CH2) m-nr10-ch2 (chr8) (ch8) n-ch2or8 - (CH2) n-co2r7, - O - (CH2) m-co2r7, - oso3h, - hatefully, h, low pitch, phenyl, or substituted phenyl; each R8 is independent, h, Al glucunido, - o-glucasa, forms (4) or (2,a. When two R6 are - or11 and adjacent propylene glycol or preparation (5), the lower end of R6 is dondquilo - (= O) - R11, glucose, 2-tetrahie;each R9 is, independently of each other in a phenyl ring, the residues aliquotly - CO2R13, -CON (R13) 2, -SO2CH2R13, or -C (= Oyl of the two R6s can be joined together to form a methylenedioxy group, each R7 is, indepe) R13; each R10 is independently H, -SO2CH3, -CO2R7, -C (= O) NR7R9, -C (= O) R7, or -CH2- (CHOH) n-CH2, H or lower alkyl; each R8 is, inOH; each Z is, independently, CHOH, C (= O),-(depends on, h, lower tar, - (= O) - R11, CH2) n -,Chn13r13, C = nr13, O N13; each R11 is, in glucose, 2-tetrahydropyridine, or formula (5);(R7) NR7, ((NR7), from R7, ((NR7), or) NR7, ((R7), from R7,,, thought, h, R7, R10, - (CH2) m-nr7r10, -(CH2) - CH2 - (CHH) n-ch2oh; each Z is independent, Choh, C (= O),CHNR7R10, C = NR10, or NR10; each R11 em-NR7R7, - (CH2) m-N + R11R11R11, - (CH2) m- (CHOR8) m- (Cs, independently, lower alkyl; each g is H2) mNR7R10, - (CH2) m-NR10R10, - (CH2) m- (CHOR8) m- (CH2) mNR7R7, - (CH2) m- (CHOR8) m- (CH2) mN + R11R11R11, as,Independently, an integer is from 1 to 6; each meter is an integer compounding group (9), provided that the 13th R13 can be combined to form 1 to 7; each n is an integer from 0 to 7; each q is independent, including a compounding group (10);C-r6, or N atom, where q is c-oh and H is independent, nr13, s,-So...-SO2...- that is...-SO2N13...-NHSO2...- No. thirteenthThe ring with the sum of o-conr1 equal to 3Q is N atom, or the same salt available for drug use, while I3 -;Each gram is an independent number, including all corresponding, symmetric and / or 1-6; each m is an independent integer, from 1 to 7; each n is the racemic mixture; (2) each R2 is an integer, from 0 to 7; each Q 'is independent, - R7, - (CH2) m-or8, - (CH2) m-n7r10, -(CH2) n (chor8) (chor8) n-ch2or8, - (CH2CH2O) m-r8, ITA, c-r6, or N, each q is independent - (CH2CH2O) m-ch2ch2n7r10, - (CH2) N-C (= O) nr7r10, - (C-C (r6r5) -,-C (R6R6) --N (R10) --N (R7) --N (R5) -H2) n-Zg-R7 - (CH2) m-NR10-CH2 (CHOR8) (CHOR8) n-CH2OR8-S--So...it is life.But the condition is, in this case, - (CH2) n-co2r7, or as a formula (2); in this case, there is at least one qes-c (r5r6) - o-n (R5), two groups, i.e. ch2or8 position is 1, 2, or 1, 3, and ring with up to three Q is - n (R7),-N (R5) -- yes.-So...I am me!each V is, independently of the other, the R8 groups can be attached together, - (CH2) m-NR7R10, - (CH2) m-NR7R7, - (CH2) to form a 1,3-dioxane or 1,3- mono- or disubstituted cyclic dioxolane; each R3 and R4 is, independently-N + R11R11R11, - (CH2) n- (CHOR8) m- (CH2) mNR7R10, - (CH2) n-NR10R10, - (CH2) n- (CHOR8) m- (CH2) mNR7R7, - (CH2), H, a group represented by the formula (6),The lower hydrocarbon, the lower hydrogen, the lower hydrocarbon, FN - (chor8) m - (CH2) Mn + r11r11r11, the condition of enil, phenyl - the lower hydrocarbon (halogenated phenyl) - when V is directly combined with the lower atom (alcoxiphenlaquil), it can also be independent R7, R10, or (R11), 2, the condition is, (Cuil) low-level asphalt, low-level NaF asphalt or low-level pyridine asphalt, in the case of setting conditions for any one of the two groups - ch2or8 determines that at least one R3 and R4 is a resolution group 1.2 - or 1.3 - compared with the other group, R8 group can be combined into a resolution group 1.3-diazo or 1.3-dptreserve (6), in which each RL is,independently -R7, - (CH2) n-OR8, -O- (CH2) m-OR8, mono- or disubstituted cyclic ioxolane; or a salt a- (CH2) n-NR7R10, -O- (CH2) m-NR7R10, (CH2) n (CHOR8) (CHceptable for pharmaceutical use thereof, and which inOR8) n-CH2OR8, -O- (CH2 ) m (CHOR8) (CHOR8) n-CH2OR8, - (C