Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes

摘要

The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.