solid product, processes for producing a solid product and for producing a stabilized nanodispersion or charged micelle, translucent liquid, medical treatment method, and device for producing solid formulations of liquid biologically active agents

摘要

SOLID PRODUCT, PROCESSES FOR THE PRODUCTION OF A SOLID PRODUCT AND FOR THE PRODUCTION OF A STABILIZED NANODISPHERE OR LOADED MICELA, TRANSLUCED LIQUID, MEDICAL TREATMENT METHOD, AND A DEVICE FOR THE PRODUCTS The present invention relates to a solid product comprising a liquid biologically active agent which is closely associated with a stabilizing agent; in particular, a solid product, which may be reconstituted as a stabilized nanodispersion, or charged micelles, comprising a polymer as a stabilizing agent and a liquid, preferably water-immiscible, biologically active agent. The present invention is further directed to a process for producing the above solid product; in particular micelles or nanodispersions produced by the hydration of a solid product cake or powder produced by effective treatment of a stabilized solution comprising, for example, a polymer as a stabilizing agent such as a block copolymer an amphiphilic or low molecular weight surfactant loaded with a liquid biologically active agent such as profofol, an optional additive, and a suitable solvent.