The process of preparau00c7u00e7o of formulations of semicarbazonas and / or tiossemicarbazonas with cyclodextrins and their derivatives and products obtained from this process

摘要

The process of preparau00c7u00e7o of formulations of semicarbazonas and / or tiossemicarbazonas with cyclodextrins and their derivatives and products obtained from this process. The present invention is characterized by the preparation of formulations of semicarbazonas and / or tiossemicarbazonas with cyclodextrins and their derivatives and products obtained from this process.The present invention is characterized by obtaining compounds of inclusion of semicarbazonas and / or tiossemicarbazonas in cyclodextrins and their derivatives tested in experimental models of epilepsy, allowed the reduction of anticonvulsant dose of loomg / kg for 35mg / kg, which can sign Ificar increase in bioavailability of compounds in biological systems.These results obtained in animal models, put semicarbazonas and / or tiossemicarbazonas included in cyclodextrins and their derivatives as candidates for new anticonvulsant agents. The present invention is characterized by increasing the effectiveness of the semicarbazonas and / or tiossemicarbazonas included in cyclodextrins and their derivatives, when compared to the free components.