CHEMICAL SYNTHESIS OF (3R,5R)-DIHYDROXY-7-2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-1-PYRROLYL-HEPTANOC ACID, CALCIUM SALT, TRIHYDRATE, PHARMACEUTICAL FORMULATION APPLICATION AND PRODUCTION PROCEDURE.

摘要

Atorvastatin is a synthetic hydroxy-methyl-glutaryl inhibitor of coenzyme A reductase (HMG-CoA), which has been proven effective in reducing cholesterol and triglycerides. The inhibitor of coenzyme A reductase has also been proven effective in lowering cholesterol and triglycerides. It is administered as calcium salt in amounts between 10 to 80 mg per day to lower the high lipid levels in patients at early stages of hyperlipidaemia or combined hyperlipidaemia. It is administered as calcium salt of the active hydroxy-carboxylic acid and is used in quantities 10 to 80 mg per day to lower the high lipid limits in patients suffering from hyperlipidaemia at early stage or for inherited hyperlipidaemia (A.P. Lea, D. Mc Tavish, Drugs 53 (1997) 828-847).