Method of industrial production of amorphous form of (3R,5R) 7-3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropylpyrrol-1-yl-3,5-dihydroxyheptanoic acid hemicalcium salt (atorvastatin) with low specific surface and use thereof in medicamento

摘要

The present invention relates to an amorphous form of (3R, 5R) 7- [3-phenyl-4-phenylcarbamoyl-2- (4-fluorophenyl) -5-isopropylpyrrol-1-yl] -3,5-dihydroxyheptanoic acid hemicalcium salt (atorvastatin of formula I) ) with a high specific surface area based on controlled precipitation and its use in dosage form.