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IMMUNOEFFECTORS AND ADJUANTS POLYACYLATED AMINOALKYL GLUCOSAMINIDE PHOSPHATE COMPOUNDS AND PHARMACEUTICAL AND VACCINE COMPOSITIONS CONTAINING THEM
IMMUNOEFFECTORS AND ADJUANTS POLYACYLATED AMINOALKYL GLUCOSAMINIDE PHOSPHATE COMPOUNDS AND PHARMACEUTICAL AND VACCINE COMPOSITIONS CONTAINING THEM
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机译:免疫原和辅酶聚酰氨基葡糖氨基磷酸磷酸盐化合物以及包含它们的药物和疫苗组合物
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摘要
Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosamine ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
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