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PYRROLO 2,1-C 1,4 BENZODIAZEPINE-GLYCOSIDE PRODRUG USEFUL AS A SELECTIVE ANTI TUMOR AGENT
PYRROLO 2,1-C 1,4 BENZODIAZEPINE-GLYCOSIDE PRODRUG USEFUL AS A SELECTIVE ANTI TUMOR AGENT
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机译:PYRROLO [2,1-C] [1,4]苯二氮卓-糖苷前体药物,用作选择性抗肿瘤药物
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摘要
The present invention provides novel pyrrolo[2,1-c][1,4]benzodiazepine-glycoside prodrug of general formula 1a-b, useful as selective anticancer agents. The present invention also provides a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine-glycoside prodrugs of general formula 1a-b. This invention also provides activation of these produgs by E.coli ß galactosidase and envisaged that these molecules are toxic to human cancer cell lines in the presence of the enzyme E.coli ß -galactosidase. The prodrugs 1a and 1b were also found to be toxic to human cancer HepG2 cells even in the absence of the E.coli D-galactosidase. The toxic effect of the molecules when activated was similar to that of the parent molecules 6a and 6b, respectively.
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